As stated in Srimad-Bhagavatam, kamam hrd-rogam. Materialistic life means that one is afflicted by a formidable disease called lusty desire. Liberation means freedom from lusty desires because it is only due to such desires that one must accept repeated birth and death. As long as ones lusty desires are unfulfilled, one must take birth after birth to fulfill them. Because of material desires, therefore, one performs various types of activities and receives various types of bodies with which to try to fulfill desires that are never satisfied. The only remedy is to take to devotional service, which begins when one is free from all material desires. Anyabhilasita-sunyam. Anya-abhilasita means material desire, and sunyam means free from. The spiritual soul has spiritual activities and spiritual desires, as described by Sri Caitanya Mahaprabhu: mama janmani janmanisvare bhavatad bhaktir ahaituki tvayi. Unalloyed devotion to the service of the Lord is the only spiritual desire. To fulfill this spiritual desire, however, one must be free from all material desires. Desirelessness means freedom from material desires. This is described by Srila Rupa Gosvami as Anyabhilasita-sunyam. As soon as one has material desires, one loses his spiritual identity. Then all the paraphernalia of ones life, including ones senses, body, religion, patience and intelligence, are deviated from ones original Krsna consciousness. As soon as one has material desires, one cannot properly use his senses, intelligence, mind and so on for the satisfaction of the Supreme Personality of Godhead. Mayavadi philosophers want to become impersonal, senseless and mindless, but that is not possible. The living entity must be living, always existing with desires, ambitions and so on. These should be purified, however, so that one can desire spiritually and be spiritually ambitious, without material contamination. In every living entity these propensities exist because he is a living entity. When materially contaminated, however, one is put into the hands of material misery (janma-mrtyu jara-vyadhi). If one wants to stop repeated birth and death, one must take to the devotional service of the Lord.