namas ta asisam isa
manave karanatmane
namo dharmaya brhate
purusaya puranaya
sankhya-yogesvaraya ca
namahoffering obeisances; teunto You; asisam isaO topmost of all bestowers of benediction; manaveunto the supreme mind or supreme Manu; karana-atmanethe supreme cause of all causes; namahoffering obeisances; dharmayaunto one who knows the best of all religion; brhatethe greatest; krsnayaunto Krsna; akuntha-medhaseunto one whose brain activity is never checked; purusayathe Supreme Person; puranayathe oldest of the old; sankhya-yoga-isvarayathe master of the principles of sankhya-yoga; caand.
My dear Lord, You are the topmost of all bestowers of all benediction, the oldest and supreme enjoyer amongst all enjoyers. You are the master of all the worlds metaphysical philosophy, for You are the supreme cause of all causes, Lord Krsna. You are the greatest of all religious principles, the supreme mind, and You have a brain which is never checked by any condition. Therefore I repeatedly offer my obeisances unto You.
The words krsnaya akuntha-medhase are significant in this verse. Modern scientists have stopped their brainwork by discovering the theory of uncertainty, but factually for a living being there cannot be any brain activity which is not checked by time and space limitations. A living entity is called anu, an atomic particle of the supreme soul, and therefore his brain is also atomic. It cannot accommodate unlimited knowledge. This does not mean, however, that the Supreme Personality of Godhead, Krsna, has a limited brain. What Krsna says and does is not limited by time and space. In Bhagavad-gita (7.26) the Lord says:
vedaham samatitani
vartamanani carjuna
bhavisyani ca bhutani
mam tu veda na kascana
O Arjuna, as the Supreme Personality of Godhead, I know everything that has happened in the past, all that is happening in the present, and all things that are yet to come. I also know all living entities; but Me no one knows.
Krsna knows everything, but one cannot know Krsna without being favored by Him. Thus for Krsna and His representative there is no question of a theory of uncertainty. What Krsna says is all perfect and certain and is applicable to the past, present and future. Nor is there any uncertainty for one who knows exactly what Krsna says. The Krsna consciousness movement is based on Bhagavad-gita as it is, as spoken by Lord Krsna, and for those who are engaged in this movement, there is no question of uncertainty.
Lord Krsna is also addressed herein as asisam isa. The great saintly personalities, sages and demigods are able to offer benedictions to ordinary living entities, but they in turn are benedicted by the Supreme Personality of Godhead. Without being benedicted by Krsna, one cannot offer benediction to anyone else. The word manave, meaning unto the supreme Manu, is also significant. The supreme Manu in Vedic literature is Svayambhuva Manu, who is an incarnation of Krsna. All the Manus are empowered incarnations of Krsna (manvantara-avatara). There are fourteen Manus in one day of Brahma, 420 in one month, all the Manus are directors of human society, ultimately Krsna is the supreme director of human society. In another sense, the word manave indicates the perfection of all kinds of mantras. The mantra delivers the conditioned soul from his bondage; so simply by chanting the mantra Hare Krsna, Hare Krsna, Krsna Krsna, Hare Hare/ Hare Rama, Hare Rama, Rama Rama, Hare Hare, one can gain deliverance from any condition.
Karanatmane: everything has a cause. The theory of chance is repudiated in this verse. Because everything has its cause, there is no question of chance. Because so-called philosophers and scientists are unable to find the real cause, they foolishly say that everything happens by chance. In Brahma-samhita Krsna is described as the cause of all causes; therefore He is addressed herein as karanatmane. His very personality is the original cause of everything, the root of everything and the seed of everything. As described in the Vedanta-sutra (1.1.2), janmady asya yatah: [SB 1.1.1] the Absolute Truth is the supreme cause of all emanations.
The word sankhya-yogesvaraya is also significant herein, for Krsna is described in Bhagavad-gita as Yogesvara, the master of all mystic powers. Without possessing inconceivable mystic powers, one cannot be accepted as God. In this age of Kali, those who have a little fragmental portion of mystic power claim to be God, but such pseudo Gods can only be accepted as fools, for only Krsna is the Supreme Person who possesses all mystic and yogic perfections. The sankhya-yoga system popular at the present moment was propounded by the atheist Kapila, but the original sankhya-yoga system was propounded by an incarnation of Krsna also named Kapila, the son of Devahuti. Similarly, Dattatreya, another incarnation of Krsna, also explained the sankhya-yoga system. Thus Krsna is the origin of all sankhya-yoga systems and mystic yoga powers.
The words purusaya puranaya are also worthy of special attention. In Brahma-samhita, Krsna is accepted as the adi-purusa, the original person, or the original enjoyer. In Bhagavad-gita, Lord Krsna is also accepted as purana-purusa, the oldest person. Although He is the oldest of all personalities, He is also the youngest of all, or nava-yauvana. Another significant word is dharmaya. Since Krsna is the original propounder of all kinds of religious principles, it is said: dharmam tu saksad bhagavat-pranitam (Bhag. 6.3.19). No one can introduce a new type of religion, for religion is already there, having been established by Lord Krsna. In Bhagavad-gita Krsna informs us of the original dharma and asks us to give up all kinds of religious principles. The real dharma is surrender unto Him. In the Mahabharata, it is also said:
The purport is that one who has studied the Vedas perfectly, who is a perfect vipra, or knower of the Vedas, who knows what spiritual life actually is, speaks about Krsna, the Supreme Person, as ones sanatana-dharma. Lord Siva therefore teaches us the principles of sanatana-dharma.

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