bhaktira virodhī karma-dharma vā adharma
tāhāra 'kalmaṣa' nāma, sei mahā-tamaḥ
bhaktira—to devotional service; virodhī—averse; karma—activity; dharma—religious; vā—or; adharma—irreligious; tāhāra—of that; kalmaṣa—sin; nāma—the name; sei—this; mahā-tamaḥ—great darkness.
The greatest ignorance consists of activities, whether religious or irreligious, that are opposed to devotional service. They are to be known as sins [kalmaṣa].
Link to this page: https://prabhupadabooks.com/cc/adi/3/61